Iran retaliated against U.S. air and cruise missile strikes as hostilities escalated Thursday with attacks against Kuwait and Bahrain in renewed fighting after U.S. President Donald Trump warned that Tehran would “pay the price” for stalled negotiations.

The exchange came shortly after the U.S. launched a second round of airstrikes overnight Thursday. Bahrain is the headquarters of the U.S. Navy's 5th Fleet.

The new assault across multiple Iranian cities came as efforts to negotiate an end the war appeared to have stalled, with Iran insisting it would maintain its grip on the Strait of Hormuz. Talks have also faltered because of Israel's attacks against the Iranian-allied Hezbollah militant group in Lebanon. On Monday, Iran and Israel targeted each other.

In a first exchange of missile fire from Iran and airstrikes by the U.S. on Wednesday, Iranian missiles were launched at missiles at Bahrain, Kuwait and Jordan. Those came in the wake of American strikes in reprisal for the shooting down of a U.S. helicopter in the strait.

The U.S. Central Command said it completed its latest round of airstrikes just before the sun rose Thursday in Iran. It said the strikes targeted military surveillance, communications and air defense sites and were carried out by the U.S. Air Force, Marines and Navy. It did not elaborate on the damage done by the strikes.

Explosions from the strikes echoed around Iran’s capital, Tehran, as well as in the port city of Bandar Abbas and other southern areas along the strait.

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Iran’s Foreign Ministry issued a statement Thursday saying the U.S. attacks had “effectively rendered the ceasefire ... meaningless,” without saying it was abandoning it.

Iran's says US attacks have rendered ceasefire meaningless

Iran’s Foreign Ministry issued a statement Thursday saying the U.S. attacks had “effectively rendered the ceasefire ... meaningless,” without saying it was abandoning it.

Pakistan expresses concern over tensions

Pakistan on Thursday expressed deep concern over rising tensions between the United States and Iran and urged both sides to adhere to a ceasefire understanding, saying Islamabad would continue efforts to promote dialogue and diplomacy.

“Pakistan reaffirms its support for the peaceful resolution of all outstanding issues,” Foreign Ministry spokesman Tahir Andrabi told a news briefing in Islamabad.

India says 3 Indian mariners killed on tanker hit by US military

An Indian official says three Indian mariners were killed on board a tanker targeted by the U.S. military over allegedly violating America’s blockade on Iran.

Indian Ports, Shipping and Waterways Minister Sarbananda Sonowal announced the three mariners’ killing on X in the attack on the Palau-flagged tanker Settebello.

“Sadly, three Indian seafarers initially reported missing are now confirmed dead after two bodies were recovered,” he wrote. It wasn’t clear where the third body was.

The U.S. military’s Central Command had accused the Settebello of having “violated the ongoing blockade by attempting to transport oil from Iran.” It fired into the ship’s engine room to stop it.

Kuwait closes its airspaces as it intercepts incoming fire

Kuwait says it has closed its airspace over ongoing Iranian attacks and said flights were being diverted to alternative airports, without elaborating.

Flights had been circling outside of Kuwait for some time before the announcement after it said its air defenses were firing.

Kuwait International Airport had taken a direct Iranian hit in recent days, which killed one person and wounded dozens.

Kuwaiti air defenses fire at incoming missiles, Bahrain sounds alerts

Kuwait's military said its air defenses were firing Thursday morning after Iran threatened retaliation for U.S. airstrikes overnight. Bahrain separately sounded its missile alert sirens in the island kingdom that hosts the U.S. Navy's 5th Fleet headquarters.